ten Tusscher-Panfilov Model of Human Ventricular Cardiac Action Potentials, 2006

This model simulates human ventricular action potentials. This is a modified version of ten Tusscher, Noble, Panfilov 2004 model that reformulates Ca²⁺ current and adds reduced version of the Markov-state ryanodine receptor model.

Abstract excerpt: "In this manuscript we study the conditions for alternans and spiral breakup in human cardiac tissue. Therefore, we develop a new version of our human ventricular cell model, which is based on recent experimental measurements of human APD restitution and includes a more extensive description of intracellular calcium dynamics."

• Ten Tusscher KH, Panfilov AV.
  Alternans and spiral breakup in a human ventricular tissue model.
  Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1088-100.
  PMID: 16565318

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