Human Ventricular TNNP04-ESM

Enhanced Simucore Model Based Upon: ten Tusscher, Noble, Panfilov Model of Human Ventricular Cardiac Action Potentials, 2004; v. 2.0

Description

Example action potential (BCL = 400 ms).
Example action potential (BCL = 400 ms).

This model simulates human ventricular action potentials. This model is based on the up-to-date experimental data for human ventricular myocytes, and contains original Ca2+ release component. Yet, the model is computationally-efficient which makes it suitable for large-scale spatial simulations.

Abstract excerpt: "In this article we introduce a mathematical model of the action potential of human ventricular cells that, while including a high level of electrophysiological detail, is computationally cost-effective enough to be applied in large-scale spatial simulations for the study of reentrant arrhythmias. The model is based on recent experimental data on most of the major ionic currents: the fast sodium, L-type calcium, transient outward, rapid and slow delayed rectifier, and inward rectifier currents. The model includes a basic calcium dynamics, allowing for the realistic modeling of calcium transients, calcium current inactivation, and the contraction staircase."

References

  • ten Tusscher KH, Noble D, Noble PJ, Panfilov AV.
    A model for human ventricular tissue.
    Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1573-89.
    PMID: 14656705

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