Guinea Pig Ventricular IKsWT-SR05-ESM

Enhanced Simucore Model Based Upon: Silva-Rudy Markovian Model of Guinea Pig Wild-Type IKs Channels in a Cardiac Ventricular Cell, 2005; v. 2.0

Description

Example action potential (BCL = 400 ms).
Example action potential (BCL = 400 ms).

This model simulates guinea pig ventricular action potentials. The orignal Hodgkin-Huxley type formulation of the slow component of the delayed-rectifier potassium current (IKs) was replaced with the Markovian model of guinea pig IKs.

References

  • Silva J, Rudy Y.
    Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve.
    Circulation. 2005 Sep 6;112(10):1384-91.
    PMID: 16129795

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