Canine Atrial RNC00-ESM

Enhanced Simucore Model Based Upon: Ramirez, Nattel, Courtemanche Model of Canine Atrial Cardiac Action Potentials, 2000; v. 2.0

Description

Example action potential (BCL = 400 ms).
Example action potential (BCL = 400 ms).

This model simulates canine atrial action potentials. The models formulation is based on Luo-Rudy II guinea-pig ventricular model with currents modified to mimic the configuration of canine atrial action potential.

Abstract excerpt: "To obtain insights into the ionic mechanisms governing canine atrial AP properties, we incorporated formulations of K(+), Na(+), Ca(2+), and Cl(-) currents, based on measurements in canine atrial myocytes, into a mathematical model of the AP."

References

  • Ramirez RJ, Nattel S, Courtemanche M.
    Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling.
    Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1767-85.
    PMID: 11009464

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