Canine Atrial KRCCN02-ESM

Enhanced Simucore Model Based Upon: Kneller, Ramirez, Chartier, Courtemanche, Nattel Model of Canine Atrial Cardiac Action Potentials, 2002; v. 2.0

Description

Example action potential after 10 iterations (BCL = 400 ms).
Example action potential after 10 iterations (BCL = 400 ms).

This model improves long-term stability of Ramirez, Nattel, Courtemanche Canine model by adding background Cl- current and Na+-Cl- cotransporter formulations. Maximal conductances of ICa, L, Ito and Iur were also adjusted to stabilize action potential configurations during long runs.

The example action potential below was recorded after 50,000 model pacings at BCL=400 ms. The action potential configuration after this >5.5h long run is very similar to the action potential recorded after only 10 iterations (above). This model is therefore suitable for simulations where long-term ionic concentration stability is required over prolonged periods of time.

Example action potential after 50,000 iterations (BCL = 400 ms).
Example action potential after 50,000 iterations (BCL = 400 ms).

Abstract excerpt: "The present study evaluated transients during long-term simulated activity in a mathematical model of the canine atrial AP."

References

  • Kneller J, Ramirez RJ, Chartier D, Courtemanche M, Nattel S.
    Time-dependent transients in an ionically based mathematical model of the canine atrial action potential.
    Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1437-51.
    PMID: 11893581

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