Canine Ventricular FMG02-ESM

Enhanced Simucore Model Based Upon: Fox, McHarg, Gilmour Model of Canine Ventricular Cardiac Action Potentials, 2002; v. 2.0

Description

Example action potential (BCL = 400 ms).
Example action potential (BCL = 400 ms).

The model is used to simulate canine ventricular action potentials. It uses modified current formulations from Luo-Rudy II guinea-pig and Winslow et al. canine ventricular models. The simplified Ca2+ handling is included.

Abstract excerpt: "...we developed a new ionic model using formulations of currents based on previous models and recent experimental data. Compared with existing models, the inward rectifier K(+) current (I(K1)) was decreased at depolarized potentials, the maximum conductance and rectification of the rapid component of the delayed rectifier K(+) current (I(Kr)) were increased, and I(Kr) activation kinetics were slowed. The slow component of the delayed rectifier K(+) current (I(Ks)) was increased in magnitude and activation shifted to less positive voltages, and the L-type Ca(2+) current (I(Ca)) was modified to produce a smaller, more rapidly inactivating current. Finally, a simplified form of intracellular calcium dynamics was adopted."

References

  • Fox JJ, McHarg JL, Gilmour RF Jr.
    Ionic mechanism of electrical alternans.
    Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H516-30.
    PMID: 11788399

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