Guinea Pig Ventricular IKrWT-CR01-ESM
Enhanced Simucore Model Based Upon: Clancy-Rudy Markovian Model of Wild-Type IKr Channels in a Cardiac Ventricular Cell, 2001; v. 2.0
Example action potential (BCL = 400 ms).
This model simulates guinea pig ventricular action potentials. The orignal Hodgkin-Huxley type formulation of the rapid component of the delayed-rectifier potassium current (IKr) was replaced with the Markovian one. It includes three closed states (C3, C2 and C1), an open, conducting state (O), and a single inactivation state (I).
Abstract excerpt: "We developed Markovian models of wild-type (WT) and mutant I(Kr) channels and incorporated these models into a comprehensive model of the cardiac ventricular cell."
- Clancy CE, Rudy Y.
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.
Cardiovasc Res. 2001 May;50(2):301-13.