Human Ventricular BWZVP02-ESM

Enhanced Simucore Model Based Upon: Bernus et al. Computationally-efficient Model of Human Ventricular Cardiac Action Potentials, 2002; v. 2.0


Example action potential (BCL = 400 ms).
Example action potential (BCL = 400 ms).

This model simulates human ventricular action potentials. This is a simplified version of Priebe-Beuckelmann human ventricular model. This model does not contain dynamic ion concentration calculations and replaces some gating variables with their steady-state values to improve computational efficiency.

Abstract excerpt: "We introduce a six-variable model obtained by a reformulation of the Priebe-Beuckelmann model of a single human ventricular cell. The reformulated model is 4.9 times faster for numerical computations and it is more stable than the original model."


  • Bernus O, Wilders R, Zemlin CW, Verschelde H, Panfilov AV.
    A computationally efficient electrophysiological model of human ventricular cells.
    Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2296-308.
    PMID: 12003840