Rabbit Ventricular PB01-SM

Simucore Model Based Upon: Puglisi-Bers Model of Rabbit Ventricular Cardiac Action Potentials, 2001; v. 1.4

Description

Example action potential (BCL = 400 ms).
Example action potential (BCL = 400 ms).

This model simulates rabbit ventricular action potentials. It is based on Luo-Rudy II model and adds two new outward currents: transient-outward current carried by potassium, and Ca2+-activated Cl- current carried by chloride. These currents contribute to the characteristic early repolarisation of the rabbit ventricular action potential. In addition, maximal conductance of the slow component of the delayed-rectifier potassium current was decreased by 50% to account for the smaller current amplitudes recorded in rabbit ventricular myocytes.

Abstract excerpt: "The model reproduces normal rabbit ventricular myocyte currents, Ca transients, and APs. We also changed parameters to simulate data from heart failure (HF) myocytes, including reduced transient outward (I(to)) and inward rectifying K currents (I(K1)), enhanced Na/Ca exchange expression, and reduced sarcoplasmic reticulum Ca-ATPase function, but unaltered Ca current density. These changes caused reduced Ca transient amplitude and increased AP duration (especially at lower frequency) as observed experimentally."

References

  • Puglisi JL, Bers DM.
    LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport.
    Am J Physiol Cell Physiol. 2001 Dec;281(6):C2049-60.
    PMID: 11698264

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