Guinea Pig Ventricular FR00-SM

Simucore Model Based Upon: Faber-Rudy Model of Mammalian Ventricular Cardiac Action Potentials, 2000; v. 1.4


Example action potential (BCL = 400 ms).
Example action potential (BCL = 400 ms).

The model is used to simulate guinea pig ventricular action potentials. It formulates ionic current gating in terms of Hodgkin-Huxley type equations. This model contains description of fourteen ionic currents and pumps. In addition, it describes the process of calcium release from the sarcoplasmic reticulum and detailed dynamics of intracellular calcium concentration changes (hence the name, "dynamic"). The original formulation of this model was subsequently updated (see References) and is being widely used as a foundation for the new cardiac myocyte model development.


  • Luo CH, Rudy Y.
    A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation.
    Circ Res. 1994 Jun;74(6):1097-113.
    PMID: 514510
  • Luo CH, Rudy Y.
    Abstract A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.
    Circ Res. 1994 Jun;74(6):1071-96.
    PMID: 7514509
  • Zeng J, Laurita KR, Rosenbaum DS, Rudy Y.
    Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization.
    Circ Res. 1995 Jul;77(1):140-52.
    PMID: 7788872
  • Shaw RM, Rudy Y.
    Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration.
    Cardiovasc Res. 1997 Aug;35(2):256-72.
    PMID: 9349389
  • Viswanathan PC, Shaw RM, Rudy Y.
    Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study.
    Circulation. 1999 May 11;99(18):2466-74.
    PMID: 10318671
  • Faber GM, Rudy Y.
    Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study.
    Biophys J. 2000 May;78(5):2392-404.
    PMID: 10777735