Guinea Pig Ventricular IKrWT-CR01-SM

Simucore Model Based Upon: Clancy-Rudy Markovian Model of Wild-Type IKr Channels in a Cardiac Ventricular Cell, 2001; v. 1.4

Description

Example action potential (BCL = 400 ms).
Example action potential (BCL = 400 ms).

This model simulates guinea pig ventricular action potentials. The orignal Hodgkin-Huxley type formulation of the rapid component of the delayed-rectifier potassium current (IKr) was replaced with the Markovian one. It includes three closed states (C3, C2 and C1), an open, conducting state (O), and a single inactivation state (I).

Abstract excerpt: "We developed Markovian models of wild-type (WT) and mutant I(Kr) channels and incorporated these models into a comprehensive model of the cardiac ventricular cell."

References

  • Clancy CE, Rudy Y.
    Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.
    Cardiovasc Res. 2001 May;50(2):301-13.
    PMID: 11334834

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